记者6月4日从中科院昆明动物所获悉，该所赖仞课题组从红瘰疣螈皮肤中鉴定出一条强效的皮肤修复肽Tylotoin。相关成果发表于《美国实验生物学学会联合会杂志》。

据了解，人们熟知的有尾目两栖动物如蝾螈，拥有非同寻常的创伤修复能力，但对其促进皮肤创伤修复的机制和可能的活性物质知之甚少。研究人员一直希望在蝾螈的皮肤上发现促进创伤修复、组织愈合的有效活性成分，这对理解蝾螈皮肤快速愈合和开发皮肤修复类药物具有重要意义。

此次科研人员从红瘰疣螈皮肤中鉴定出一条强效的皮肤修复肽Tylotoin，其仅含有12个氨基酸残基。在小鼠全层皮损模型中，它表现出强烈的促创伤愈合活性。Tylotoin可促进角质细胞和成纤维细胞的增殖和迁移，从而促进受损皮肤上皮化和肉芽组织的形成。同时，该修复肽能促进与创伤愈合有密切关系的TGF-β1和IL-6的生成。（来源：中国科学报 张雯雯）

A potential wound-healing-promoting peptide from salamander skin

Abstract  Although it is well known that wound healing proceeds incredibly quickly in urodele amphibians, such as newts and salamanders, little is known about skin-wound healing, and no bioactive/effector substance that contributes to wound healing has been identified from these animals. As a step toward understanding salamander wound healing and skin regeneration, a potential wound-healing-promoting peptide (tylotoin; KCVRQNNKRVCK) was identified from salamander skin of Tylototriton verrucosus. It shows comparable wound-healing-promoting ability (EC₅₀=11.14 μg/ml) with epidermal growth factor (EGF; NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELR) in a murine model of full-thickness dermal wound. Tylotoin directly enhances the motility and proliferation of keratinocytes, vascular endothelial cells, and fibroblasts, resulting in accelerated reepithelialization and granulation tissue formation in the wound site. Tylotoin also promotes the release of transforming growth factor β1 (TGF-β1) and interleukin 6 (IL-6), which are essential in the wound healing response. Gene-encoded tylotoin secreted in salamander skin is possibly an effector molecule for skin wound healing. This study may facilitate understanding of the cellular and molecular events that underlie quick wound healing in salamanders.

原文链接：http://www.fasebj.org/content/early/2014/05/26/fj.13-248476.full.pdf+html