报告名称：Nanoparticle and Nature Products for Cancer Therapy

报告人：晏为力 博士

Assistant Professor, School of Pharmacy, Auburn University

报告时间：2009年12月23日（星期三）上午10:00点

报告地点：成都生物所综合楼二楼会议室

报告人简介：

Research and Professional Experience:

11/2009 – Present, Assistant Professor, School of Pharmacy, Auburn University

06/2008 – 10/2009, Scientist I, Enzon Pharmaceuticals, Inc. Piscataway, NJ

03/2006 – 06/2008, Postdoctoral Associate, School of Pharmacy, University of NC at Chapel Hill

08/2001 - 02/2006, Graduate Student and Research Assistant, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY

Professional Memberships:

2003-present　  American Association of Pharmaceutical Scientists

2004-present　  American Association of Cancer Research　　

1.　　　　  Molecular pharmaceutics and drug delivery: Molecular mechanistic understanding of drug delivery and drug delivery systems. Lipid- based nano-particle and liposome for targeted and intracellular delivery of protein, peptide, DNA, siRNA, miRNA, vaccine and drugs for treatment of cancer and infectious diseases. Development and physiochemical characterization of novel particulate delivery system for biological macromolecules. Protein and nucleic acid drug pre-formulation characterization, formulation design and stability study.

2.　　　　  Cancer immunology, immunotherapy and anti-cancer drug pharmacology. Signal transduction in antigen presenting cells and nature products as immune stimulators for cancer therapy. Signal transduction in tumor cell transformation, proliferation and apoptosis. Anti-cancer drug screening, drug resistance mechanism and targeted delivery of anti-cancer drugs based on the tumor specific molecules or signal transduction.

Honors:

Dissertation Enhancement Award, Graduate School, University of Kentucky, 2004

S. Elizabeth Helton Spring Travel Award, College of Pharmacy, University of Kentucky, 2003

Di’ao excellent thesis reward, Chinese Academy of Sciences, 1999

Publications:

2. Weili Yan and Leaf Huang. (2009) The Effects of Salt on the Physicochemical Properties and Immunogenicity of Protein Based Vaccine Formulated in Cationic Liposome. International Journal of Pharmaceutics. 368:56-62

3. Weili Yan, Weihsu Chen and Leaf Huang. (2009) Bryostatin-I: a potent dendritic cell stimulator and a promising adjuvant for peptide based cancer vaccine. Cancer Immunol Immunother, Submitted.

4. Weili Yan, Weihsu Chen and Leaf Huang. (2008) Reactive oxygen species play a central role in the adjuvant activity of cationic liposome. J of Controlled Release, 130:22-8. 

5. Weihsu Chen, Weili Yan, and Leaf Huang. (2008) A simple but effective cancer vaccine consisting of an antigen and a cationic lipid. Cancer Immunol Immunother, 57:517-30.

6. Weili Yan, Weihsu Chen and Leaf Huang (2007) Mechanism of adjuvant activity of cationic liposome: phosphorylation of a map kinase, ERK, and induction of chemokines. Molecular immunology, 44: 3672-3681.

8. Wei J., Yan, Weili,Li X., Chang W.C., and Tai H.H. (2007) Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. Biochem Pharmacol, 74:787-800.

9. Yan, Weili, Ding, Y. and Tai, H.H. 14-3-3ζ interacts with thromboxane receptors and is involved in the agonist-induced transactivation of the ERK. Biochem Pharmacol, 2006, 71:624-633.　　

10. Yan, Weili and Tai, H.H., Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation and cell morphology change following stimulation of thromboxane receptor. J Pharmacol Exp Ther, 2006, 317: 267-274.

11. Huang, X., Yan, Weili, Gao, D., Tong, M., Tai, H.H., Zhan, C.G. Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. Bioorg Med Chem, 2006, 14:3553-3562.

12. Wu, X., Bu, X., Wong, K.M., Yan, Weili, Guo Z. Biomimetic synthesis of gramicidins and analogues by enzymatic cyclization of linear precursors on solid support. Org Lett. 2003, 5:1749-1752

13. Xie, G., Uttamchandani, M., Chen, G.Y., Bu, X., Lin, S.S., Wong, K.M., Yan, Weili, Yao SQ, Guo Z. Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters. Bioorg Med Chem Lett. 2002, 12:989-992

14. Yan, Weili, Pu, Q., Meng, Y. Preparation of sulfates of two Polygonatum polysaccharides and their antiviral activities. Tianran Chanwu Yanjiu Yu Kaifa. 2000, 12: 60-65. In Chinese.

Invited Reviews:

YAN, W., Huang, L. (2007) Recent advances in liposome-based nanoparticles for antigen delivery. Poly Rev. 47: 329-344.

2. Weili Yan andHsin-Hsiung Tai,14-3-3ζ interacts with thromboxane receptors and is involved in the agonist-induced transactivation of the ERK. AAPS Annual Meeting Prceedings, #W5039, 2005

4. Leaf Huang, Weili Yan and Weihsu Chen, Dendritic Cell Activation and Antigen Delivery by Cationic Lipids. 2007 Control Release Society Annual Meeting.

5. Weili Yan, Weihsu Chen and Leaf Huang, Mechanism of adjuvant activity of cationic liposome. The AAPS Journal. Vol. 9, No. S2, Abstract T3049 (2007).

6. Hong Zhao, Puja Sapra, Lianjun (David) Shi, Weili Yan, Dechun Wu, Jun Xu,　  Maoliang Wang, Mary Mehlig, Jennifer Malaby, Patricia Kraft, Yoany Lozanguiez, Maksim Royzen, Nishith Sanghvi, Lee M. Greenberger, Ivan D. Horak. Novel releasable PEG-nanoparticles enhance delivery of RNA antagonist oligonucleotides in tumor cells and in mice. AACR 2009 Annual Meeting Proceedings.

Invited Talk:

Leaf Huang, Weili Yan, Weihsu Chen and Shyh-Dar Li, Dendritic Cell Activation and Antigen Delivery by Cationic Lipids. NHRI- International symposium on “Vaccine from Research to Product Launch”. Taiwan, 2007.

Patents:

1.Stimulation of an immune response by cationic lipids, Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, and Leaf Huang. 2008, 12/049,957.

2.A cationic-lipid based dual function delivery system and immune stimulant for treatment of disease, Weishu Chen, Weili Yan and Leaf Huang, 60/948,512.

3. Releasable Cationic Lipid ketal Zhao, H., Shi, L., Yan, Weili, Wu, D.US Patent Application 61/115365, November 17, 2008

4. Releasable Cationic Lipids Imine Zhao, H., Shi, L., Yan, Weili, Wu, D.US Patent Application 61/115348, November 17, 2008

Scientific Journal Reviewer:

Cancer Immunology, Immunotherapy

Molecular Immunology

Vaccine

Molecular Therapy