- 青琳森
- 电子邮件：qingls@cib.ac.cn
- 职 称：研究员
- 学 历：博士研究生
个人简历
青琳森，男，1981年9月生，四川南充人，执业药师，研究员、博士生导师
教育经历：
1999.9 - 2003.6 华西医科大学，药学院，药学专业本科
2003.9 - 2006.6 四川大学，华西药学院，生药学专业硕士
2008.9 - 2011.6 中国科学院成都生物研究所，药物化学专业博士
工作经历：
2006.7 - 2008.8 成都地奥制药集团，药物研究所
2011.7 - 2013.6 中国科学院成都生物研究所，博士后
2013.7至今 中国科学院成都生物研究所，副研究员、研究员
研究方向
天然活性成分研究与新药开发
社会任职
四川省药学会中药与天然药专委会委员
四川省分析测试学会有机质谱专委会理事
中国人民政治协商会议成都市第十六届委员会委员
获奖及荣誉
承担科研项目情况
主持：
1. 中央引导地方科技发展资金项目，2022.9-2023.8
2. 四川省科技计划国际/港澳台科技创新合作项目，2022.1-2023.12
3. 中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化平台项目，2021.10-2024.12
4. 浙江佐力药业股份有限公司委托项目，2021.3-2024.3
5. 四川省科技计划重点研发项目，2019.1-2020.12
6. 中国科学院西部青年学者（院内A类）项目，2019.1-2021.12
7. 中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化平台项目，2018.8-2021.7
8. 中国博士后科学基金第6批特别资助，2013.6-2016.6
9. 中国科学院西部博士人才培养计划，2013.1-2016.6
10. 国家自然科学基金青年基金，2013.1-2015.12
11. 中国博士后科学基金第50批面上资助，2011.9-2013.12
同时参与国家自然科学基金、四川省科技计划、香港特区政府卫生署项目、澳门科学技术发展基金等多项课题的研究。
代表论著
科研论文（一作/通讯，含并列）：
1. Xiao-Feng Huang, et al. Chemical derivatization strategies for enhancing HPLC analytical performance of natural active triterpenoids. Journal of Pharmaceutical Analysis. 2024, 14(3): 295-307.
2. Xiao-Yi Chen, et al. Preclinical investigations on anti-fibrotic potential of long-term oral therapy of sodium astragalosidate in animal models of cardiac and renal fibrosis. ACS Pharmacology & Translational Science. 2024, 7(2): 421-431.
3. Shan-Shan Song, et al. Role of simulated in vitro gastrointestinal digestion on biotransformation and bioactivity of astragalosides from Radix Astragali, Journal of Pharmaceutical and Biomedical Analysis, 2023, 231: 115414.
4. Qian-Long Wang, et al. Surface hydrolysis-designed AuNPs-zwitterionic-glucose as a novel tool for targeting macrophage visualization and delivery into infarcted hearts, Journal of Controlled Release, 2023, 356: 678-690.
5. Lin-Sen Qing, et al. Microfluidic strategies for natural products in drug discovery: Current status and future perspectives. Trends in Analytical Chemistry, 2023, 158: 116832.
6. You-Jiao Wu, et al. Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos. Frontiers in Pharmacology, 2022, 13: 987882.
7. Tian-Tian Wang, et al. Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review. Advanced Sensor and Energy Materials, 2022, 1(3): 100016.
8. Qian-Long Wang, et al. Non-invasion prognosis of post-myocardial infarction using urinary miRNA ultra-trace detection based on single target DNA functionalized AuNPs. ACS Applied Materials & Interfaces, 2022, 14(3): 3633-3642.
9. Ming-Qing Tang, et al. Advances in aptamer-based sensing assays for C-reactive protein. Analytical and Bioanalytical Chemistry, 2022, 414(2): 867-884.
10. Jing Xie, et al. Determination of nine nucleosides in Rhizoma Paridis by quantitative analysis of multi-components via a single marker method. Journal of Separation Science, 2021, 44(9): 1866-1874.
11. Li Chen, et al. Astragaloside IV derivative (LS-102) alleviated myocardial ischemia reperfusion injury by inhibiting Drp1Ser616 phosphorylation-mediated mitochondrial fission. Frontiers in Pharmacology, 2020, 11: 1083.
12. Ming-Qing Tang, et al. Research progress of C-reactive protein analysis. Chinese Journal of Analytical Chemistry, 2020, 48(9): 1121-1130.
13. Tian-Tian Wang, et al. A feasible image-based colorimetric assay using a smartphone RGB camera for point-of-care monitoring of diabetes. Talanta, 2020, 206: 120211.
14. Qian-Long Wang, et al. Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1 ) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic. Microchimica Acta, 2020, 187(1): 61.
15. Chao-Xi Chen, et al. A new strategy for the preparation of antibody against natural glycoside: With astragaloside IV as an example. Fitoterapia, 2020, 142: 104488.
