1980.09-1984.07 四川大学化学系，获理学学士学位

1984.09-1987.07 兰州大学化学系有机合成专业，获理学硕士学位

1987.07-1990.09 中国科学院成都生物研究所，从事天然药物化学研究，助研（1989.07）

1990.09-1993.09 波恩大学数学——自然科学学院药物研究所，获理学博士学位。

1993.09-1994.12 波恩大学数学——自然科学学院药物研究所，从事抗肿瘤活性天然产物的研究

1995.01-1996.11 北京大学化学与分子工程学院有机化学研究所，博士后,从事天然有机化学的研究                 

1996.11-  中国科学院成都生物研究所从事天然药物化学的研究，研究员（1997）、博士生导师（1999）

1999   入选“百千万人才工程”

2001   中国科学院青年科学家奖

2003   入选“四川省学术技术带头人”

2004   第七届四川省青年科技奖

2006   中国科学院优秀教师

2006   四川省优秀回国人员

2007   国务院政府特殊津贴

2013   四川省人民政府，四川省科学技术进步奖，一等奖（2/9）

2022.1-2026.12 国家自然科学基金重大项目课题，濒危药材独特疗效物质研究——濒危药材复杂体系中独特疗效物质的精准表征

2019.01-2022.12 国家自然科学基金面上项目，

毛壳霉中新颖多聚吲哚生物碱的结构与活性

2019.01-2021.12 国家自然科学基金国际（地区）合作与交流项目，（NSFC-TRF项目)，基于天然产物的老年性疾病候选药物研究

2018.1-2020.12 国家重大新药创制(科技部)课题，具重要生物活性的天然小分子化合物的高效鉴定

2016.01-2018.12 国家自然科学基金国际（地区）合作与交流项目，（NSFC-TRF项目)，治疗老年性疾病的天然产物药物发现研究

2014.01-2017.12 国家自然科学基金面上项目，苯并呋喃：基于分子内脱羧、C-O键形成的合成与芳香化酶抑制活性

2013.01-2015.12 国家自然科学基金重大研究计划集成项目课题，基于小分子探针的细胞命运决定的分子机制研究——调控JAK-STAT信号过程的天然产物

2012.01-2015.12 国家自然科学基金面上项目，淫羊藿苷及类似物的合成与构效关系研究

2010.01-2013.12 国家自然科学基金重点项目，天然产物对雌激素合成和代谢调控机制的研究

2009.01-2013.12 国家重点基础研究发展计划（973计划）课题, 确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究

1. Jing Wang, Xueqing Qian, Tao Yang, Dabin Hou, Guolin Zhang,* Guoyou Li，* Chaetomadramines A–E, a Class of Siderophores with Potent Neuroprotective Activity from the Fungus Chaetomium madrasense cib-1, Fitoterapia, 2023, 164: 105351. 

2. Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Fei Wang, Guolin Zhang,* Yinggang Luo, * Hunteriasines A – D, Tryptamine-derived Alkaloids from Hunteria umbellate, Phytochemistry, 2023, 213: 113572..

3. Xueqing Qian,^# Guobo Xu,^# Lingyan Liu, Tao Yang, Guolin Zhang,* Guoyou Li,* Chaetonigrisins A–L, A Group of 3-Indole-1,2-propanediol Derived Alkaloids from Chaetomium nigricolor YT-2, Bioorganic Chemistry, 2022, 130:106201.

4. Ting Peng,^# Yujiao He,^# Tao Wang,^# Jialing Yu,^# Xiaofang Ma,^# Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu,* Xiaoxia Lu,* Guolin Zhang,* Fei Wang,* Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP−Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Journal of Medicinal Chenistry, 2022, 65: 11010−11033.  

5. Xuejian Zhang,^# Yu Cao,^# Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* Yinggang Luo,* Antifibrotic Pyridine-containing Monoterpene Alkaloids from Caryopteris glutinosa, Phytochemistry, 2022,203:113378

6. Yuwen Sheng,^# Yuwen Chen,^# Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang,* Wei Jiao, * Fei Wang,* Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming，Journal of Medicinal Chemistry, 2022, 65: 460−484.

7. Naijie Fu, Ruiying Xi, Xiaoke Shi, Runze Li, Zhonghui Zhang, Lingyu Li, Guolin Zhang,* Fei Wang,* Hexachlorophene, a Selective SHP2 Inhibitor, Suppresses Proliferation and Metastasis of KRAS-mutant NSCLC Cells by Inhibiting RAS/MEK/ERK and PI3K/AKT Signaling Pathways,Toxicology and Applied Pharmacology, 2022, 441: 115988

8. Xuejian Zhang, Guoyong Luo, Yu Cao, Dumaa Mishig, Munkhgerel Lodonjav, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* Yinggang Luo，* ( )-Caryopterisines A and B, Dimeric Monoterpene Alkaloids with Unprecedented 6/5/5/5/6 Pentacyclic Rings Scaffold from Caryopteris glutinosa，Bioorganic Chemistry, 2021, 116: 105364.

9. Wisanee Wisanwattana,^# Kanjana Wongkrajang,^# Dongyi Cao, Xiaoke Shi, Zhonghui Zhang, Zongyuan Zhou, Fu Li, Qinggang Mei, Chun Wang, Apichart Suksamrarn, Guolin Zhang,* Fei Wang，* Inhibition of Phosphodiesterase 5 Promotes the Aromatase- Mediated Eestrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway, Frontiers in Endocrinology, 2021, 12: Article 636784.

10. Ting Peng, Orawan Wonganan , Zhonghui Zhang , Jialing Yu , Ruiying Xi , Yu Cao , Apichart Suksamrarn , Guolin Zhang,* Fei Wang，* A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating  -TrCP E3 Ubiquitin Ligase，International Journal of Molecular Sciences, 2021, 22: 3354.

11. Wei Xiong,^# Xiaohong Wang,^# Xianyan Shen, Cuifang Hu, Xin Wang, Fei Wang, Guolin Zhang,* Chun Wang,* Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone, Journal of Organic Chemistry, 2020, 85: 13160-13176.

12. Xuejian Zhang, Ting Peng, Xiaoke Shi, Dongmei Fang, Lin Tang, Fang Chen, Fei Wang, Guolin Zhang，* Yingguo Luo,*  Diterpenoids Caryopterisoids D - Q and Iridoid Glucoside Derivatives Caryopterisides F-H from Caryopteris glutinosa, Phytochemistry, 2020, 180: 112534