Configuration Confirmation of Euphorbia Factor L1 by Single-crystal X-ray Diffraction
稿件作者：焦威
通讯作者：鲁润华
刊物名称：结构化学
发表年份：2008
卷：27
期：12
页码：1431-1434
影响因子：0.643
文章摘要：
A 6,(17)-epoxylathyrol diterpenoid ((2S*3S*4R*5R*6S*9S*11S*15R*)-5,15-diacetoxy-3-
phenylacetoxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide) was isolated from the seeds of
Euhporbia lathyris L. Its configuration was puzzled because of the incomplete X-ray results reported
before. In this work, the atom connectivity and configuration were confirmed by single-crystal X-ray
diffraction together with ESI-MS, 1H-, and 13C-NMR spectroscopy. The compound crystallizes in
monoclinic, space group P21 with a = 11.386(1), b = 8.2839(7), c = 17.192(2) Å, β = 108.305(2)º, Z
= 2, V = 1539.5(2) Å3, C32H40O8, Mr = 552.64, Dc = 1.192 g/m3, F(000) = 592, μ(MoKα) = 0.085
mm−1, T = 293(2) K, the final R = 0.0398 and wR = 0.0950 for 2057 observed reflections with I >
2σ(I). The molecule shows a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and
three-membered rings. The configuration at C(5) is R* and that at C(6) S*.
phenylacetoxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide) was isolated from the seeds of
Euhporbia lathyris L. Its configuration was puzzled because of the incomplete X-ray results reported
before. In this work, the atom connectivity and configuration were confirmed by single-crystal X-ray
diffraction together with ESI-MS, 1H-, and 13C-NMR spectroscopy. The compound crystallizes in
monoclinic, space group P21 with a = 11.386(1), b = 8.2839(7), c = 17.192(2) Å, β = 108.305(2)º, Z
= 2, V = 1539.5(2) Å3, C32H40O8, Mr = 552.64, Dc = 1.192 g/m3, F(000) = 592, μ(MoKα) = 0.085
mm−1, T = 293(2) K, the final R = 0.0398 and wR = 0.0950 for 2057 observed reflections with I >
2σ(I). The molecule shows a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and
three-membered rings. The configuration at C(5) is R* and that at C(6) S*.
